Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

The discovery of therapeutic monoclonal antibodies (mAbs) mainly focuses on the biological activity they support the selection of highly potent drug candidates. these candidates, however, may have the physical attributes or chemical that causes a chemical that is not profitable, manufacturing, and controls (CMC) properties, such as titer inferior products, conformation and colloidal instability or poor solubility, which can inhibit or even prevent the development and manufacturing , Therefore, there is an urgent need to consider developability mAb candidates for lead identification and optimization.

This work provides a comprehensive proof of concept studies to significantly improve the developability of mAb variants that are optimized with the help of advanced in silico tool relative to the co-parenting a difficult-to-develop. Interestingly, a single amino acid substitutions in the variable domain of the light chain resulted in a three fold increase in titer of products after stable expression in Chinese hamster ovary cells. Microscopic investigation revealed that the wild type mAb-producing cells show potential inclusion antibody, whereas the cells in silico-producing optimized variants showed phenotype rescued.

Notably, the drug substance of variants in silico optimized contained substantially reduced levels of aggregate and fragment after the purification process downstream. Finally, the study formulations biodegrade significantly enhanced colloidal stability in silico optimized variants while folding and potential stability is maintained. This study emphasizes that the implementation of the initial bioinformatics lead generation and optimization of biotherapeutics reduce failures for further development activities and to support the reduction schedule and project resources.

 Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain
Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

The quality and cost assessment of recombinant antibody fragments produced from mammalian, yeast and prokaryotic host cells: A case study before the development of pharmaceuticals.

monoclonal antibody fragment (Fab) are a promising class of therapeutic agents. Beatles aglycosylated protein expression and so many platforms have been developed including prokaryotic, yeast and mammalian cells. However, these platforms are not equal in terms of development of cell lines and culture time, product quality and the possibility of production costs greatly affect the success of the development of pharmaceutical drug candidates. This study is a humanized Fab fragment ACT017 ratings generated from two organisms (Escherichia coli and Pichia pastoris) and a host mammalian cell (CHO).

Following low production scale and Protein L-affinity purification in a generic condition, physico-chemical and functional quality of the assessment carried out prior to the economic analysis of industrial scale production using special software (Biosolve, Biopharm Services, UK).

The results showed a high titer production when using E. coli but related to the high heterogeneity of the protein content in the supernatant recovered. We also observed from Fab glycoforms produced from P. pastoris, while Fab secreted from CHO is the most homogeneous culture despite a longer time and a slightly higher estimate of the cost of goods. This study may help inform future pharmaceutical development of this class of therapeutic proteins.

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx032323-80l 80 µl
EUR 343.2

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx036573-100ug 100 ug
EUR 469.2

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx001218
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx211205
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  • 100 ul
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx211206
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx230209-100ug 100 ug
EUR 577.2

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx175289
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx171123
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx324550
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx130064-100l 100 µl
EUR 262.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx130064-1ml 1 ml
EUR 725

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx130064-200l 200 µl
EUR 337.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx171123-1ml 1 ml
EUR 712.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx036573-100g 100 µg
EUR 337.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx230209-100g 100 µg
EUR 350

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104577-100g 100 µg
EUR 675

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104577-20g 20 µg
EUR 250

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104577-50g 50 µg
EUR 312.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104578-100g 100 µg
EUR 687.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104578-20g 20 µg
EUR 262.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104578-50g 50 µg
EUR 325

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair

abx117558-1pair5x96wellplates 1 pair (5x96 well plates)
EUR 1212

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair

20-abx370664
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  • 10 × 96 tests
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair

abx370664-100g 100 µg
EUR 2312.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair

abx370664-50g 50 µg
EUR 1437.5

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2016284-01mL 0.1mL
EUR 165

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2016284-02mL 0.2mL
EUR 200

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2016284-05mL 0.5mL
EUR 325

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2016284-1mL 1mL
EUR 395

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2016284-5mL 5mL
EUR 1075

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2027218-01mL 0.1mL
EUR 170

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2027218-02mL 0.2mL
EUR 215

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2027218-05mL 0.5mL
EUR 350

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2027218-1mL 1mL
EUR 425

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2027218-5mL 5mL
EUR 1160

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2005468-01mL 0.1mL
EUR 170

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2005468-02mL 0.2mL
EUR 205

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2005468-05mL 0.5mL
EUR 330

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2005468-1mL 1mL
EUR 405

Polyclonal Antibody to Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2005468-5mL 5mL
EUR 1100

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

4-RPA645Hu01
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Description: Recombinant Human Advanced Glycosylation End Product Specific Receptor expressed in: E.coli

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

4-RPA645Mu01
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Description: Recombinant Mouse Advanced Glycosylation End Product Specific Receptor expressed in: E.coli

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

4-RPA645Ra01
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Description: Recombinant Rat Advanced Glycosylation End Product Specific Receptor expressed in: E.coli

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2018483-001mg 0.01mg
EUR 180

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2018483-005mg 0.05mg
EUR 330

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2018483-01mg 0.1mg
EUR 500

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2018483-02mg 0.2mg
EUR 615

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2018483-05mg 0.5mg
EUR 1170

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2029915-001mg 0.01mg
EUR 175

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2029915-005mg 0.05mg
EUR 320

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2029915-01mg 0.1mg
EUR 490

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2029915-02mg 0.2mg
EUR 595

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2029915-05mg 0.5mg
EUR 1130

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2009621-001mg 0.01mg
EUR 170

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2009621-005mg 0.05mg
EUR 295

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2009621-01mg 0.1mg
EUR 445

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2009621-02mg 0.2mg
EUR 540

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

MBS2009621-05mg 0.5mg
EUR 1025

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat)

4-PAA645Ra01
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER)

Rat Advanced Glycosylation End Product Specific Receptor (AGER) Protein

20-abx168527
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Rat Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx168527-1ml 1 ml
EUR 225

Human Advanced Glycosylation End Product Specific Receptor (AGER) Protein

20-abx065184
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Mouse Advanced Glycosylation End Product Specific Receptor (AGER) Protein

20-abx065185
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Human Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065184-100g 100 µg
EUR 425

Human Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065184-200g 200 µg
EUR 625

Human Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065184-50g 50 µg
EUR 237.5

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065185-100g 100 µg
EUR 387.5

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065185-200g 200 µg
EUR 550

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065185-50g 50 µg
EUR 212.5

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), APC

4-PAA645Ra01-APC
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with APC.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), Cy3

4-PAA645Ra01-Cy3
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with Cy3.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), HRP

4-PAA645Ra01-HRP
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with HRP.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), PE

4-PAA645Ra01-PE
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with PE.

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (AP)

MBS6405783-01mL 0.1mL
EUR 950

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (AP)

MBS6405783-5x01mL 5x0.1mL
EUR 4120

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (PE)

MBS6405793-01mL 0.1mL
EUR 950

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (PE)

MBS6405793-5x01mL 5x0.1mL
EUR 4120

Rat Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196214-96tests 96 tests
EUR 990

Rat Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196214-100l 100 µl Ask for price

Rat Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196214-50l 50 µl
EUR 618.75

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Mouse, Rat)

4-PAA645Mu01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse, Rat Advanced Glycosylation End Product Specific Receptor (AGER)

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), FITC

4-PAA645Ra01-FITC
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with FITC.

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (APC)

MBS6405784-01mL 0.1mL
EUR 950

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (APC)

MBS6405784-5x01mL 5x0.1mL
EUR 4120

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (FITC)

MBS6405786-01mL 0.1mL
EUR 950

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (FITC)

MBS6405786-5x01mL 5x0.1mL
EUR 4120

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (HRP)

MBS6405787-01mL 0.1mL
EUR 950

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (HRP)

MBS6405787-5x01mL 5x0.1mL
EUR 4120

Rat AGER (Advanced Glycosylation End Product Specific Receptor) CLIA Kit

MBS2530941-5x96Tests 5x96Tests
EUR 2565

Rat AGER (Advanced Glycosylation End Product Specific Receptor) CLIA Kit

MBS2530941-96Tests 96Tests
EUR 560

Human Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196212-96tests 96 tests
EUR 990

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196213-96tests 96 tests
EUR 990

Cow Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx518938-96tests 96 tests
EUR 1093.2

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx518941-96tests 96 tests
EUR 904.8

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx256697-96tests 96 tests
EUR 904.8

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

20-abx156891
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Pig Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx362083-96tests 96 tests
EUR 990

Mouse Advanced Glycosylation End Product Specific Receptor (AGER)CLIA Kit

SCA645Mu-10x96wellstestplate 10x96-wells test plate
EUR 6965.86
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER)CLIA Kit

SCA645Mu-1x48wellstestplate 1x48-wells test plate
EUR 678.84
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER)CLIA Kit

SCA645Mu-1x96wellstestplate 1x96-wells test plate
EUR 918.34
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER)CLIA Kit

SCA645Mu-5x96wellstestplate 5x96-wells test plate
EUR 3772.51
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

4-SCA645Mu
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  • 10 plates of 96 wells
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  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Ra-10x96wellstestplate 10x96-wells test plate
EUR 5552.14
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Ra-1x48wellstestplate 1x48-wells test plate
EUR 562.42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Ra-1x96wellstestplate 1x96-wells test plate
EUR 752.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Ra-5x96wellstestplate 5x96-wells test plate
EUR 3024.07
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

4-SEA645Ra
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  • 10 plates of 96 wells
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  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx156891-100g 100 µg
EUR 6075

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx156891-10g 10 µg
EUR 675

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx156891-50g 50 µg
EUR 3212.5

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx256697-1096tests 10 × 96 tests Ask for price

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx256697-596tests 5 × 96 tests Ask for price

Human Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196212-100l 100 µl
EUR 618.75

Human Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196212-200l 200 µl Ask for price

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196213-100l 100 µl Ask for price

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196213-50l 50 µl
EUR 618.75

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2024834-10x96StripWells 10x96-Strip-Wells
EUR 5220

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2024834-24StripWells 24-Strip-Wells
EUR 355

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2024834-48StripWells 48-Strip-Wells
EUR 535

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2024834-5x96StripWells 5x96-Strip-Wells
EUR 2860

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2024834-96StripWells 96-Strip-Wells
EUR 705

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

MBS2025292-10x96StripWells 10x96-Strip-Wells
EUR 6315

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

MBS2025292-24StripWells 24-Strip-Wells
EUR 415

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

MBS2025292-48StripWells 48-Strip-Wells
EUR 640

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

MBS2025292-5x96StripWells 5x96-Strip-Wells
EUR 3480

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

MBS2025292-96StripWells 96-Strip-Wells
EUR 865

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2702212-10x96StripWells 10x96-Strip-Wells
EUR 3060

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2702212-24StripWells 24-Strip-Wells
EUR 250

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2702212-48StripWells 48-Strip-Wells
EUR 325

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2702212-5x96StripWells 5x96-Strip-Wells
EUR 1595

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

MBS2702212-96StripWells 96-Strip-Wells
EUR 410

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Human, Mouse)

4-PAA645Hu01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human, Mouse Advanced Glycosylation End Product Specific Receptor (AGER)

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (Biotin)

MBS6405785-01mL 0.1mL
EUR 950

AGER (Advanced Glycosylation End Product Specific Receptor, MGC22357, RAGE, AGER) (Biotin)

MBS6405785-5x01mL 5x0.1mL
EUR 4120

Rat AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

ELK5184-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat AGER. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat AGER. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat AGER, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat AGER in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

ELK5184-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat AGER. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat AGER. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat AGER, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat AGER in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

E39ER0723 96T
EUR 595

Rat AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

MBS8804178-10x96StripWells 10x96-Strip-Wells
EUR 3130

Rat AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

MBS8804178-48StripWells 48-Strip-Wells
EUR 350

Rat AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

MBS8804178-5x96StripWells 5x96-Strip-Wells
EUR 1710

Rat AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

MBS8804178-96StripWells 96-Strip-Wells
EUR 445

Human AGER (Advanced Glycosylation End Product Specific Receptor) CLIA Kit

MBS2532217-5x96Tests 5x96Tests
EUR 2565

Human AGER (Advanced Glycosylation End Product Specific Receptor) CLIA Kit

MBS2532217-96Tests 96Tests
EUR 560

Mouse AGER (Advanced Glycosylation End Product Specific Receptor) CLIA Kit

MBS2533008-5x96Tests 5x96Tests
EUR 2565

Mouse AGER (Advanced Glycosylation End Product Specific Receptor) CLIA Kit

MBS2533008-96Tests 96Tests
EUR 560

Rat AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

MBS2509793-10x96Tests 10x96Tests
EUR 4060

Rat AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

MBS2509793-24Tests 24Tests
EUR 265

Rat AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

MBS2509793-48Tests 48Tests
EUR 450

Rat AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

MBS2509793-5x96Tests 5x96Tests
EUR 2265

Rat AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

MBS2509793-96Tests 96Tests
EUR 535

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

20-abx153607
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

20-abx150586
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx254878-96tests 96 tests
EUR 848.4

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx252019-96tests 96 tests
EUR 848.4

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx253583-96tests 96 tests
EUR 848.4

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx518940-96tests 96 tests
EUR 848.4

Rabbit Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx362340-96tests 96 tests
EUR 990

Sheep Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx364692-96tests 96 tests
EUR 1111.2

Monkey Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx360317-96tests 96 tests
EUR 990

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Hu 96T
EUR 422
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Mu 96T
EUR 432
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Mu-48T 48T
EUR 586.8
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Mu-96T 96T
EUR 762
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DL-AGER-Hu 96T
EUR 402
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DL-AGER-Mu 96T
EUR 412
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

EK12506 96Т
EUR 768

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

EK12507 96Т
EUR 768

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RD-AGER-Hu-48T 48T
EUR 411.8
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.


Names and indications of therapeutic monoclonal antibodies must comply with applicable regulations, which do not prevent the development of commercial strategies across the tradename. Some of these practices are based on legal considerations or the region while others are motivated by a real medical concerns. Finally, some have a significant financial impact on society.