Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

The discovery of therapeutic monoclonal antibodies (mAbs) mainly focuses on the biological activity they support the selection of highly potent drug candidates. these candidates, however, may have the physical attributes or chemical that causes a chemical that is not profitable, manufacturing, and controls (CMC) properties, such as titer inferior products, conformation and colloidal instability or poor solubility, which can inhibit or even prevent the development and manufacturing , Therefore, there is an urgent need to consider developability mAb candidates for lead identification and optimization.

This work provides a comprehensive proof of concept studies to significantly improve the developability of mAb variants that are optimized with the help of advanced in silico tool relative to the co-parenting a difficult-to-develop. Interestingly, a single amino acid substitutions in the variable domain of the light chain resulted in a three fold increase in titer of products after stable expression in Chinese hamster ovary cells. Microscopic investigation revealed that the wild type mAb-producing cells show potential inclusion antibody, whereas the cells in silico-producing optimized variants showed phenotype rescued.

Notably, the drug substance of variants in silico optimized contained substantially reduced levels of aggregate and fragment after the purification process downstream. Finally, the study formulations biodegrade significantly enhanced colloidal stability in silico optimized variants while folding and potential stability is maintained. This study emphasizes that the implementation of the initial bioinformatics lead generation and optimization of biotherapeutics reduce failures for further development activities and to support the reduction schedule and project resources.

 Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain
Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

The quality and cost assessment of recombinant antibody fragments produced from mammalian, yeast and prokaryotic host cells: A case study before the development of pharmaceuticals.

monoclonal antibody fragment (Fab) are a promising class of therapeutic agents. Beatles aglycosylated protein expression and so many platforms have been developed including prokaryotic, yeast and mammalian cells. However, these platforms are not equal in terms of development of cell lines and culture time, product quality and the possibility of production costs greatly affect the success of the development of pharmaceutical drug candidates. This study is a humanized Fab fragment ACT017 ratings generated from two organisms (Escherichia coli and Pichia pastoris) and a host mammalian cell (CHO).

Following low production scale and Protein L-affinity purification in a generic condition, physico-chemical and functional quality of the assessment carried out prior to the economic analysis of industrial scale production using special software (Biosolve, Biopharm Services, UK).

The results showed a high titer production when using E. coli but related to the high heterogeneity of the protein content in the supernatant recovered. We also observed from Fab glycoforms produced from P. pastoris, while Fab secreted from CHO is the most homogeneous culture despite a longer time and a slightly higher estimate of the cost of goods. This study may help inform future pharmaceutical development of this class of therapeutic proteins.

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx211206
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx175289
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  • 1 mg
  • 200 ug

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx171123
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  • 1 mg
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx230209-100ug 100 ug
EUR 577.2

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx104577
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  • 100 ug
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx104578
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  • 100 ug
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

20-abx001218
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx032323-400ul 400 ul
EUR 627.6

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx032323-80l 80 µl
EUR 343.2

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx230209-100g 100 µg
EUR 350

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx130064-100l 100 µl
EUR 262.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx130064-1ml 1 ml
EUR 725

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx130064-200l 200 µl
EUR 337.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104577-100g 100 µg
EUR 675

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104577-20g 20 µg
EUR 250

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104577-50g 50 µg
EUR 312.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104578-100g 100 µg
EUR 687.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104578-20g 20 µg
EUR 262.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx104578-50g 50 µg
EUR 325

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx036573-100g 100 µg
EUR 337.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody

abx171123-1ml 1 ml
EUR 712.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair

20-abx370664
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  • 10 × 96 tests
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Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair

abx117558-1pair5x96wellplates 1 pair (5x96 well plates)
EUR 1212

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair

abx370664-100g 100 µg
EUR 2312.5

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair

abx370664-50g 50 µg
EUR 1437.5

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

4-RPA645Hu01
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Description: Recombinant Human Advanced Glycosylation End Product Specific Receptor expressed in: E.coli

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

4-RPA645Mu01
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Description: Recombinant Mouse Advanced Glycosylation End Product Specific Receptor expressed in: E.coli

Recombinant Advanced Glycosylation End Product Specific Receptor (AGER)

4-RPA645Ra01
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  • 100 ug
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Description: Recombinant Rat Advanced Glycosylation End Product Specific Receptor expressed in: E.coli

Rat Advanced Glycosylation End Product Specific Receptor (AGER) Protein

20-abx168527
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Rat Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx168527-1ml 1 ml
EUR 225

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat)

4-PAA645Ra01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER)

Human Advanced Glycosylation End Product Specific Receptor (AGER) Protein

20-abx065184
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  • 100 ug
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Mouse Advanced Glycosylation End Product Specific Receptor (AGER) Protein

20-abx065185
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  • 100 ug
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Human Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065184-100g 100 µg
EUR 425

Human Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065184-200g 200 µg
EUR 625

Human Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065184-50g 50 µg
EUR 237.5

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065185-100g 100 µg
EUR 387.5

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065185-200g 200 µg
EUR 550

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) Protein

abx065185-50g 50 µg
EUR 212.5

Rat Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196214-96tests 96 tests
EUR 990

Rat Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196214-100l 100 µl Ask for price

Rat Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196214-50l 50 µl
EUR 618.75

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), APC

4-PAA645Ra01-APC
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with APC.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), Cy3

4-PAA645Ra01-Cy3
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with Cy3.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), HRP

4-PAA645Ra01-HRP
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with HRP.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), PE

4-PAA645Ra01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with PE.

Cow Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx518938-96tests 96 tests
EUR 1093.2

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx518941-96tests 96 tests
EUR 904.8

Pig Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx362083-96tests 96 tests
EUR 990

Human Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196212-96tests 96 tests
EUR 990

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196213-96tests 96 tests
EUR 990

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx256697-96tests 96 tests
EUR 904.8

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

20-abx156891
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  • 10 × 96 tests
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Mouse Advanced Glycosylation End Product Specific Receptor (AGER)CLIA Kit

SCA645Mu-10x96wellstestplate 10x96-wells test plate
EUR 6965.86
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER)CLIA Kit

SCA645Mu-1x48wellstestplate 1x48-wells test plate
EUR 678.84
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER)CLIA Kit

SCA645Mu-1x96wellstestplate 1x96-wells test plate
EUR 918.34
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER)CLIA Kit

SCA645Mu-5x96wellstestplate 5x96-wells test plate
EUR 3772.51
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

4-SCA645Mu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Ra-10x96wellstestplate 10x96-wells test plate
EUR 5552.14
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Ra-1x48wellstestplate 1x48-wells test plate
EUR 562.42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Ra-1x96wellstestplate 1x96-wells test plate
EUR 752.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Ra-5x96wellstestplate 5x96-wells test plate
EUR 3024.07
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

4-SEA645Ra
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx256697-1096tests 10 × 96 tests Ask for price

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx256697-596tests 5 × 96 tests Ask for price

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx156891-100g 100 µg
EUR 6075

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx156891-10g 10 µg
EUR 675

Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx156891-50g 50 µg
EUR 3212.5

Human Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196212-100l 100 µl
EUR 618.75

Human Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196212-200l 200 µl Ask for price

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196213-100l 100 µl Ask for price

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit

abx196213-50l 50 µl
EUR 618.75

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Mouse, Rat)

4-PAA645Mu01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse, Rat Advanced Glycosylation End Product Specific Receptor (AGER)

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), FITC

4-PAA645Ra01-FITC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with FITC.

Rat AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

ELK5184-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat AGER. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat AGER. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat AGER, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat AGER in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

ELK5184-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat AGER. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat AGER. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat AGER, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat AGER in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

E39ER0723 96T
EUR 595

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Hu 96T
EUR 422
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Mu 96T
EUR 432
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Mu-48T 48T
EUR 586.8
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DLR-AGER-Mu-96T 96T
EUR 762
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DL-AGER-Hu 96T
EUR 402
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

DL-AGER-Mu 96T
EUR 412
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

EK12506 96Т
EUR 768

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

EK12507 96Т
EUR 768

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx518940-96tests 96 tests
EUR 848.4

Rabbit Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx362340-96tests 96 tests
EUR 990

Sheep Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx364692-96tests 96 tests
EUR 1111.2

Monkey Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx360317-96tests 96 tests
EUR 990

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx252019-96tests 96 tests
EUR 848.4

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx253583-96tests 96 tests
EUR 848.4

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx254878-96tests 96 tests
EUR 848.4

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

20-abx153607
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

20-abx150586
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RDR-AGER-Hu-48T 48T
EUR 432.39
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RDR-AGER-Hu-48Tests 48 Tests
EUR 600

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RDR-AGER-Hu-96T 96T
EUR 617.72
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RDR-AGER-Hu-96Tests 96 Tests
EUR 830.4

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RDR-AGER-Mu-48T 48T
EUR 443.42
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RDR-AGER-Mu-48Tests 48 Tests
EUR 613.2

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RDR-AGER-Mu-96T 96T
EUR 633.47
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RDR-AGER-Mu-96Tests 96 Tests
EUR 850.8

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

4-SEA645Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Mu-10x96wellstestplate 10x96-wells test plate
EUR 5269.39
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Mu-1x48wellstestplate 1x48-wells test plate
EUR 539.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Mu-1x96wellstestplate 1x96-wells test plate
EUR 718.75
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

SEA645Mu-5x96wellstestplate 5x96-wells test plate
EUR 2874.38
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

4-SEA645Mu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Advanced Glycosylation End Product Specific Receptor (AGER) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RD-AGER-Hu-48T 48T
EUR 411.8
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RD-AGER-Hu-48Tests 48 Tests
EUR 573.6

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RD-AGER-Hu-96T 96T
EUR 588.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RD-AGER-Hu-96Tests 96 Tests
EUR 794.4

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RD-AGER-Mu-48T 48T
EUR 422.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RD-AGER-Mu-48Tests 48 Tests
EUR 586.8

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RD-AGER-Mu-96T 96T
EUR 603.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

RD-AGER-Mu-96Tests 96 Tests
EUR 812.4

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Human, Mouse)

4-PAA645Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Advanced Glycosylation End Product Specific Receptor (AGER)

Mouse AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

ELK3005-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse AGER. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse AGER. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse AGER, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse AGER in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

ELK3005-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse AGER. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse AGER. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse AGER, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse AGER in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

EM0526 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 75pg/ml

Human AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

ELK1852-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human AGER. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human AGER. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human AGER, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human AGER in the samples is then determined by comparing the OD of the samples to the standard curve.

Human AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

ELK1852-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human AGER. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human AGER. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human AGER, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human AGER in the samples is then determined by comparing the OD of the samples to the standard curve.

Human AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

EKE60221-5x96T 5x96T
EUR 3124.08

Human AGER (Advanced Glycosylation End Product Specific Receptor) ELISA Kit

EKE60221-96T 96T
EUR 657.7

Mouse AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

EKF60527-48T 48T
EUR 396.9

Mouse AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

EKF60527-5x96T 5x96T
EUR 2693.25

Mouse AGER(Advanced Glycosylation End Product Specific Receptor) ELISA Kit

EKF60527-96T 96T
EUR 567

Human Advanced Glycosylation End Product Specific Receptor ELISA Kit (AGER)

RK00844 96 Tests
EUR 280

Chicken Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx356938-96tests 96 tests
EUR 990

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Mouse, Rat), PE

4-PAA645Mu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with PE.

ELISA kit for Rat AGER (Advanced Glycosylation End Product Specific Receptor)

ELK5184 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Advanced Glycosylation End Product Specific Receptor from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Rat Advanced Glycosylation End Product Specific Receptor / RAGE (AGER) CLIA Kit

20-abx491821
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), Biotinylated

4-PAA645Ra01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with Biotin.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Human, Mouse), APC

4-PAA645Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with APC.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Human, Mouse), Cy3

4-PAA645Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with Cy3.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Human, Mouse), FITC

4-PAA645Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with FITC.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Human, Mouse), HRP

4-PAA645Hu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with HRP.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Human, Mouse), PE

4-PAA645Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with PE.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Mouse, Rat), APC

4-PAA645Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with APC.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Mouse, Rat), Cy3

4-PAA645Mu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with Cy3.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Mouse, Rat), FITC

4-PAA645Mu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with FITC.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Mouse, Rat), HRP

4-PAA645Mu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with HRP.

Advanced Glycosylation End Product Specific Receptor (AGER) Polyclonal Antibody (Rat), APC-Cy7

4-PAA645Ra01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Advanced Glycosylation End Product Specific Receptor (AGER). This antibody is labeled with APC-Cy7.

ELISA kit for Mouse AGER (Advanced Glycosylation End Product Specific Receptor)

ELK3005 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Advanced Glycosylation End Product Specific Receptor from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human AGER (Advanced Glycosylation End Product Specific Receptor)

ELK1852 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Advanced Glycosylation End Product Specific Receptor from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human Advanced Glycosylation End Product Specific Receptor / RAGE (AGER) CLIA Kit

20-abx491820
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat AGER(Total Advanced Glycosylation End Product Specific Receptor) ELISA Kit

RE1152R-48wells 48 wells
EUR 125.55

Rat AGER(Total Advanced Glycosylation End Product Specific Receptor) ELISA Kit

RE1152R-96wells 96 wells
EUR 179.55

Rat AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-R0466-24Tests 24 Tests
EUR 180
Description: Sandwich

Rat AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-R0466-48Tests 48 Tests
EUR 546
Description: Sandwich

Rat AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-R0466-96Tests 96 Tests
EUR 682
Description: Sandwich

Rat AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-R0466-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Rat AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-R0466-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Guinea pig Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit

abx358241-96tests 96 tests
EUR 990

Human AGER(Total Advanced Glycosylation End Product Specific Receptor) ELISA Kit

RE1152H-48wells 48 wells
EUR 125.55

Human AGER(Total Advanced Glycosylation End Product Specific Receptor) ELISA Kit

RE1152H-96wells 96 wells
EUR 179.55

Mouse AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-M0111-24Tests 24 Tests
EUR 180
Description: Sandwich

Mouse AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-M0111-48Tests 48 Tests
EUR 546
Description: Sandwich

Mouse AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-M0111-96Tests 96 Tests
EUR 682
Description: Sandwich

Mouse AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-M0111-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Mouse AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-M0111-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-H0241-24Tests 24 Tests
EUR 180
Description: Sandwich

Human AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-H0241-48Tests 48 Tests
EUR 546
Description: Sandwich

Human AGER -Total Advanced Glycosylation End Product Specific Receptor- CLIA Kit

E-CL-H0241-96Tests 96 Tests
EUR 682
Description: Sandwich


Names and indications of therapeutic monoclonal antibodies must comply with applicable regulations, which do not prevent the development of commercial strategies across the tradename. Some of these practices are based on legal considerations or the region while others are motivated by a real medical concerns. Finally, some have a significant financial impact on society.